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Article

A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population.

Fundamental & clinical pharmacology - 1 Jun 2012

Alshatwi Ali A, Hasan Tarique N, Shafi Gowhar, Alsaif Mohammed A, Al-Hazzani Amal A, Alsaif Adulaziz A

Abstract excerpt

Breast cancer is the most common oncological disease in women worldwide. Genetic predisposition to breast cancer can be associated with single-nucleotide polymorphisms (SNPs), which are observed in many women. Such gene polymorphisms, in combination with nutritional and environmental factors, can affect breast cancer development. The tumor suppressor TP53 and its negative regulator MDM2 play crucial roles in...

Topics

Adult
Arabs
Breast Neoplasms
Case-Control Studies
Ethnicity
Female
Genetic Predisposition to Disease
Humans
Middle Aged
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-mdm2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 21477265
DOI: 10.1111/j.1472-8206.2011.00939.x

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population.PMID 21477265Read ↗

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