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Article

Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk: an updated meta-analysis.

Molecular biology reports - 1 Sept 2012

Cheng Hongtao, Ma Biao, Jiang Ran, Wang Wei, Guo Hui, Shen Na, Li Dapeng, Zhao Qunzi, Wang Rui, Yi Pengfei, Zhao Yue, Liu Zeming, Huang Tao

Abstract excerpt

The tumor suppressor gene TP53 and its negative regulator murine double minute 2 are involved in multiple cellular pathways. Two potentially functional single nucleotide polymorphisms (SNPs) MDM2 SNP309 and TP53 R72P have been extensively investigated to be associated with breast cancer risk. However, the original studies as well as the subsequent meta-analysis, have yielded contradictory results for the...

Topics

Alleles
Breast Neoplasms
Epistasis, Genetic
Female
Gene Frequency
Genotype
Humans
Odds Ratio
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-mdm2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Publication Bias

Risk

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 22729912
DOI: 10.1007/s11033-012-1800-z

Genes

MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk: an updated meta-analysis.PMID 22729912Read ↗

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