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Frequencies of CYP2D6 genetic polymorphisms in Arab populations.

Human genomics - 5 Feb 2022

Alali Mousa, Ismail Al-Khalil Wouroud, Rijjal Sara, Al-Salhi Lana, Saifo Maher, Youssef Lama A

Abstract excerpt

CYP2D6 is a key drug-metabolizing enzyme implicated in the biotransformation of approximately 25% of currently prescribed drugs. Interindividual and interethnic differences in CYP2D6 enzymatic activity, and hence variability in substrate drug efficacy and safety, are attributed to a highly polymorphic corresponding gene. This study aims at reviewing the frequencies of the most clinically relevant CYP2D6 alleles...

Topics

Alleles
Arabs
Cytochrome P-450 CYP2D6
Gene Frequency
Humans
Polymorphism, Genetic

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35123571
DOI: 10.1186/s40246-022-00378-z
PMCID: PMC8817534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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