Article
Interethnic variation of CYP2C19 alleles, 'predicted' phenotypes and 'measured' metabolic phenotypes across world populations.
The pharmacogenomics journal - 1 Apr 2016
Fricke-Galindo I, Céspedes-Garro C, Rodrigues-Soares F, Naranjo M E G, Delgado Á, de Andrés F, López-López M, Peñas-Lledó E, LLerena A
Abstract excerpt
The present study evaluates the worldwide frequency distribution of CYP2C19 alleles and CYP2C19 metabolic phenotypes ('predicted' from genotypes and 'measured' with a probe drug) among healthy volunteers from different ethnic groups and geographic regions, as well as the relationship between the 'predicted' and 'measured' CYP2C19 metabolic phenotypes. A total of 52 181 healthy volunteers were studied within 138...
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