CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure.

doi:10.1097/01.fpc.0000239974.69464.f2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure.

Pharmacogenetics and genomics - 1 Feb 2007

Sistonen Johanna, Sajantila Antti, Lao Oscar, Corander Jukka, Barbujani Guido, Fuselli Silvia

Abstract excerpt

BACKGROUND AND OBJECTIVE: CYP2D6, a member of the cytochrome P450 superfamily, is responsible for the metabolism of about 25% of the commonly prescribed drugs. Its activity ranges from complete deficiency to excessive activity, potentially causing toxicity of medication or therapeutic failure with recommended drug dosages. This study aimed to describe the CYP2D6 diversity at the global level. METHODS: A total of...

Topics

Analysis of Variance
Chromosomes, Human, Pair 22
Cluster Analysis
Cytochrome P-450 CYP2D6
Gene Frequency
Genetic Variation
Genetics, Population
Geography
Haplotypes
Humans
Linkage Disequilibrium
Phenotype

Source

Open in PubMed

Identifiers

PMID: 17301689
DOI: 10.1097/01.fpc.0000239974.69464.f2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics