Article
Prevalence of the CYP2D6*10 (C100T), *4 (G1846A), and *14 (G1758A) alleles among Iranians of different ethnicities.
Drug design, development and therapy - 1 Jan 2015
Bagheri Ali, Kamalidehghan Behnam, Haghshenas Maryam, Azadfar Parisa, Akbari Leila, Sangtarash Mohammad Hossein, Vejdandoust Faramarz, Ahmadipour Fatemeh, Meng Goh Yong, Houshmand Massoud
Abstract excerpt
The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. Here, we compared the prevalence of the CYP2D6*10, *4, and 14* alleles in an Iranian population of different ethnicities with those of other populations. Allele and genotype frequency distributions of CYP2D6*10 variants and predicted phenotypes including...
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