Article
Distribution of CYP2D6 alleles and phenotypes in the Brazilian population.
PloS one - 1 Jan 2014
Friedrich Deise C, Genro Júlia P, Sortica Vinicius A, Suarez-Kurtz Guilherme, de Moraes Maria Elizabete, Pena Sergio D J, dos Santos Andrea K Ribeiro, Romano-Silva Marco A, Hutz Mara H
Abstract excerpt
The CYP2D6 enzyme is one of the most important members of the cytochrome P450 superfamily. This enzyme metabolizes approximately 25% of currently prescribed medications. The CYP2D6 gene presents a high allele heterogeneity that determines great inter-individual variation. The aim of this study was to evaluate the variability of CYP2D6 alleles, genotypes and predicted phenotypes in Brazilians. Eleven single...
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