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Article

Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity.

eLife - 13 Oct 2014

Howard Conor J, Hanson-Smith Victor, Kennedy Kristopher J, Miller Chad J, Lou Hua Jane, Johnson Alexander D, Turk Benjamin E, Holt Liam J

Abstract excerpt

Protein kinases have evolved diverse specificities to enable cellular information processing. To gain insight into the mechanisms underlying kinase diversification, we studied the CMGC protein kinases using ancestral reconstruction. Within this group, the cyclin dependent kinases (CDKs) and mitogen activated protein kinases (MAPKs) require proline at the +1 position of their substrates, while Ime2 prefers...

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Identifiers

PMID: 25310241
DOI: 10.7554/eLife.04126
PMCID: PMC4228266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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