Article
Evolution of protein phosphorylation across 18 fungal species.
Science (New York, N.Y.) - 14 Oct 2016
Studer Romain A, Rodriguez-Mias Ricard A, Haas Kelsey M, Hsu Joanne I, Viéitez Cristina, Solé Carme, Swaney Danielle L, Stanford Lindsay B, Liachko Ivan, Böttcher René, Dunham Maitreya J, de Nadal Eulàlia, Posas Francesc, Beltrao Pedro, Villén Judit
Abstract excerpt
Living organisms have evolved protein phosphorylation, a rapid and versatile mechanism that drives signaling and regulates protein function. We report the phosphoproteomes of 18 fungal species and a phylogenetic-based approach to study phosphosite evolution. We observe rapid divergence, with only a small fraction of phosphosites conserved over hundreds of millions of years. Relative to recently acquired...
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