Article

Evolutionary history of MEK1 illuminates the nature of cancer and RASopathy mutations

2023-03-09

Abstract excerpt

Mutations in signal transduction pathways lead to various diseases including cancers. MEK1 kinase, encoded by the human MAP2K1 gene, is one of the central components of the MAPK pathway and more than a hundred somatic mutations in MAP2K1 gene were identified in various tumors. Germline mutations deregulating MEK1 also lead to congenital abnormalities, such as the Cardiofaciocutaneous Syndrome and Arteriovenous M...

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Literature Corpus work: 26e78ffd-3e49-5b66-8676-7eb898b18f11
DOI: 10.1101/2023.03.09.531944

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