Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The repertoire of protein kinases encoded in the draft version of the human genome: atypical variations and uncommon domain combinations.

Genome biology - 1 Jan 2002

Krupa A, Srinivasan N

Abstract excerpt

BACKGROUND: Phosphorylation by protein kinases is central to cellular signal transduction. Abnormal functioning of kinases has been implicated in developmental disorders and malignancies. Their activity is regulated by second messengers and by the binding of associated domains, which are also influential in translocating the catalytic component to their substrate sites, in mediating interaction with other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Caenorhabditis elegans
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Genetic

Share to Protein Kinases

Share to Sequence Homology, Nucleic Acid

Share to src Homology Domains

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 12537555
DOI: 10.1186/gb-2002-3-12-research0066
PMCID: PMC151168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The repertoire of protein kinases encoded in the draft version of the human genome: atypical variations and uncommon domain combinations.PMID 12537555Read ↗

Systematic analysis of human kinase genes: a large number of genes and alternative splicing events result in functional and structural diversity.Semantic proximity Read ↗

Kinase mutations in human disease: interpreting genotype-phenotype relationships.Semantic proximity Read ↗

Kinase Interaction Network Expands Functional and Disease Roles of Human KinasesSemantic proximity Read ↗

Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation.Semantic proximity Read ↗

The protein tyrosine kinase family of the human genomeSemantic proximity Read ↗

The Landscape of Atypical and Eukaryotic Protein Kinases.Semantic proximity Read ↗

Kinases and CancerSemantic proximity Read ↗

A resource for exploring the understudied human kinome for research and therapeutic opportunitiesSemantic proximity Read ↗

Predisposing deleterious variants in the cancer-associated human kinases in the global populations.Semantic proximity Read ↗

Recognition of sites of functional specialisation in all known eukaryotic protein kinase families.Semantic proximity Read ↗

A global atlas of substrate specificities for the human serine/threonine kinomeSemantic proximity Read ↗

Analysis of Kinase Gene Expression Patterns across 5681 Human Tissue Samples Reveals Functional Genomic Taxonomy of the KinomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.