Article

Evolution and Engineering of Allosteric Regulation in Protein Kinases

2017-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Allosteric regulation – the control of protein function by sites far from the active site – is a common feature of proteins that enables dynamic cellular responses. Reversible modifications such as phosphorylation are well suited to mediate such regulatory dynamics, yet the evolution of new allosteric regulation demands explanation. To understand this, we mutationally scanned the surface of a pr...

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Literature Corpus work: 9d386fec-6700-5f41-b932-7d1f4721fd03
DOI: 10.1101/189761

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