Article

Ancestral protein reconstruction reveals the mechanism of substrate specificity in FN3K-mediated deglycation

2025-07-31

Abstract excerpt

Protein glycation is a detrimental byproduct of living cells’ reliance on carbohydrate metabolism, and nearly all organisms encode kinases that facilitate the removal of early glycation products. In humans, these repair functions are performed by Fructosamine-3 kinase (FN3K) and Ketosamine-3 kinase (KT3K) enzymes which share conserved catalytic mechanisms but differ in substrate specificity. Recent structural stud...

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Literature Corpus work: 647681b7-a8a7-5e2e-b0ae-1e6433558c6a
DOI: 10.1101/2025.07.30.667714

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