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Article

The role of linkage disequilibrium in case-only studies of gene-environment interactions.

Human genetics - 1 Jan 2015

Yadav Pankaj, Freitag-Wolf Sandra, Lieb Wolfgang, Krawczak Michael

Abstract excerpt

Gene-environment (G × E) interactions have been invoked to account, at least in part, for the gap between the known heritability of common human diseases and the phenotypic variation hitherto explained by genetic variants. Noteworthy in this context, a case-only (CO) design has been proposed in the past as a means to detect G × E interactions possibly more efficiently than by using classical case-control and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25304818
DOI: 10.1007/s00439-014-1497-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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