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Article

Genotype imputation in case-only studies of gene-environment interaction: validity and power.

Human genetics - 1 Aug 2021

Aleknonytė-Resch Milda, Szymczak Silke, Freitag-Wolf Sandra, Dempfle Astrid, Krawczak Michael

Abstract excerpt

Case-only (CO) studies are a powerful means to uncover gene-environment (G × E) interactions for complex human diseases. Moreover, such studies may in principle also draw upon genotype imputation to increase statistical power even further. However, genotype imputation usually employs healthy controls such as the Haplotype Reference Consortium (HRC) data as an imputation base, which may systematically perturb CO...

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Identifiers

PMID: 34041609
DOI: 10.1007/s00439-021-02294-z
PMCID: PMC8263402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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