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Article

Enhancing the power to detect low-frequency variants in genome-wide screens.

Genetics - 1 Apr 2014

Lin Chang-Yun, Xing Guan, Ku Hung-Chih, Elston Robert C, Xing Chao

Abstract excerpt

In genetic association studies a conventional test statistic is proportional to the correlation coefficient between the trait and the variant, with the result that it lacks power to detect association for low-frequency variants. Considering the link between the conventional association test statistics and the linkage disequilibrium measure r(2), we propose a test statistic analogous to the standardized linkage...

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Identifiers

PMID: 24496013
DOI: 10.1534/genetics.113.160739
PMCID: PMC3982702

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