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Article

Evaluation of gene-environment interactions for colorectal cancer susceptibility loci using case-only and case-control designs.

BMC cancer - 18 Dec 2019

Song Nan, Lee Jeeyoo, Cho Sooyoung, Kim Jeongseon, Oh Jae Hwan, Shin Aesun

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified more than 40 colorectal cancer susceptibility loci, but only a small fraction of heritability was explained. To account for missing heritability, we investigated gene-environment interactions (G × Es) between GWAS-identified single-nucleotide polymorphisms (SNPs) and established risk or protective factors for colorectal cancer using both case-only...

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Identifiers

PMID: 31849324
DOI: 10.1186/s12885-019-6456-9
PMCID: PMC6918639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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