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Article

A meta-analysis approach with filtering for identifying gene-level gene-environment interactions.

Genetic epidemiology - 1 Jul 2018

Wang Jiebiao, Liu Qianying, Pierce Brandon L, Huo Dezheng, Olopade Olufunmilayo I, Ahsan Habibul, Chen Lin S

Abstract excerpt

There is a growing recognition that gene-environment interaction (G × E) plays a pivotal role in the development and progression of complex diseases. Despite a wealth of genetic data on various complex diseases/traits generated from association and sequencing studies, detecting G × E via genome-wide analysis remains challenging due to power issues. In genome-wide G × E studies, a common strategy to improve power...

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PMID: 29430690
DOI: 10.1002/gepi.22115
PMCID: PMC6013347

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