Article

Genotype Imputation in Case-Only Studies of Gene-Environment Interaction: Validity and Power

2021-03-05

Abstract excerpt

<title>Abstract</title> <p>Case-only (CO) studies are a powerful means to uncover gene-environment (G×E) interactions for complex human diseases. Moreover, such studies may in principle also draw upon genotype imputation to increase statistical power even further. However, genotype imputation usually employs healthy controls such as the Haplotype Reference Consortium (HRC) data as an imputation base, which may sy...

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Literature Corpus work: bda542a3-81a7-547a-8ca7-38bd65372932
DOI: 10.21203/rs.3.rs-274423/v1

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