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Article

The case-combined-control design was efficient in detecting gene-environment interactions.

Journal of clinical epidemiology - 1 Jul 2004

Andrieu N, Goldstein A M

Abstract excerpt

OBJECTIVE: The interest in studying gene-environment (GxE) interaction is increasing for complex diseases. A design combining both related and unrelated controls (e.g., population-based and siblings) is proposed to increase the power to detect GxE interaction. STUDY DESIGN AND SETTING: We used simulations to assess the efficiency of the case-combined-control design relative to a classical case-control study under...

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Identifiers

PMID: 15358394
DOI: 10.1016/j.jclinepi.2003.11.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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