Article
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution.
Science (New York, N.Y.) - 10 Oct 2014
de Bruin Elza C, McGranahan Nicholas, Mitter Richard, Salm Max, Wedge David C, Yates Lucy, Jamal-Hanjani Mariam, Shafi Seema, Murugaesu Nirupa, Rowan Andrew J, Grönroos Eva, Muhammad Madiha A, Horswell Stuart, Gerlinger Marco, Varela Ignacio, Jones David, Marshall John, Voet Thierry, Van Loo Peter, Rassl Doris M, Rintoul Robert C, Janes Sam M, Lee Siow-Ming, Forster Martin, Ahmad Tanya, Lawrence David, Falzon Mary, Capitanio Arrigo, Harkins Timothy T, Lee Clarence C, Tom Warren, Teefe Enock, Chen Shann-Ching, Begum Sharmin, Rabinowitz Adam, Phillimore Benjamin, Spencer-Dene Bradley, Stamp Gordon, Szallasi Zoltan, Matthews Nik, Stewart Aengus, Campbell Peter, Swanton Charles
Abstract excerpt
Spatial and temporal dissection of the genomic changes occurring during the evolution of human non-small cell lung cancer (NSCLC) may help elucidate the basis for its dismal prognosis. We sequenced 25 spatially distinct regions from seven operable NSCLCs and found evidence of branched evolution, with driver mutations arising before and after subclonal diversification. There was pronounced intratumor heterogeneity...
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