Article
1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients.
PloS one - 1 Jan 2014
Van Belle Tom L, Vanherwegen An-Sofie, Feyaerts Dorien, De Clercq Pierre, Verstuyf Annemieke, Korf Hannelie, Gysemans Conny, Mathieu Chantal
Abstract excerpt
The emergence of regulatory T cells (Tregs) as central mediators of peripheral tolerance in the immune system has led to an important area of clinical investigation to target these cells for the treatment of autoimmune diseases such as type 1 diabetes. We have demonstrated earlier that in vitro treatment of T cells from healthy individuals with TX527, a low-calcemic analog of bioactive vitamin D, can promote a...
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