Article
Expansion of human regulatory T-cells from patients with type 1 diabetes.
Diabetes - 1 Mar 2009
Putnam Amy L, Brusko Todd M, Lee Michael R, Liu Weihong, Szot Gregory L, Ghosh Taumoha, Atkinson Mark A, Bluestone Jeffrey A
Abstract excerpt
OBJECTIVE: Regulatory T-cells (Tregs) have catalyzed the field of immune regulation. However, translating Treg-based therapies from animal models of autoimmunity to human clinical trials requires robust methods for the isolation and expansion of these cells-a need forming the basis for these studies. RESEARCH DESIGN AND METHODS: Tregs from recent-onset type 1 diabetic patients and healthy control subjects were...
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