CD137+CD154− Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures

Abstract excerpt

Regulatory T cells (Treg) are an attractive therapeutic tool for several different immune pathologies. Therapeutic Treg application often requires prolonged in vitro culture to generate sufficient Treg numbers or to optimize their functionality, e.g. via genetic engineering of their antigen receptors. However, purity of clinical Treg expansion cultures is highly variable and it is currently impossible to identify...

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