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Article

CD4+CD25(int) T cells in inflammatory diseases refractory to treatment with glucocorticoids.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2007

Lee Richard W J, Creed Thomas J, Schewitz Lauren P, Newcomb Paul V, Nicholson Lindsay B, Dick Andrew D, Dayan Colin M

Abstract excerpt

Up to 30% of patients with autoimmune, allergic, and lymphoproliferative diseases are refractory to glucocorticoid therapy. The present study was undertaken to investigate whether such steroid resistance (SR) is limited to a subpopulation of CD4(+) T cells and, as IL-2 is a putative driver of SR, whether T cell SR is associated with CD25 expression. We show that SR patients have a characteristic subgroup of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18025242
DOI: 10.4049/jimmunol.179.11.7941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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