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Article

Physiological levels of 25-hydroxyvitamin D3 induce a suppressive CD4+ T cell phenotype not reflected in the epigenetic landscape.

Scandinavian journal of immunology - 1 May 2022

Matos Carina, Renner Kathrin, Peuker Alice, Schoenhammer Gabriele, Schreiber Laura, Bruss Christina, Eder Ruediger, Bruns Heiko, Flamann Cindy, Hoffmann Petra, Gebhard Claudia, Herr Wolfgang, Rehli Michael, Peter Katrin, Kreutz Marina

Abstract excerpt

1,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ), the active metabolite of vitamin D3 has a strong impact on the differentiation and function of immune cells. Here we analysed the influence of its precursor 25-hydroxyvitamin D3 (25(OH)D3 ) on the differentiation of human CD4+ T cells applying physiological concentrations in vitro. Our data show that 25(OH)D3 is converted to its active form 1,25(OH)2 D3 by T cells, which...

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PMID: 35073416
DOI: 10.1111/sji.13146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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