Article
Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells.
The Journal of allergy and clinical immunology - 1 Jun 2011
van der Aar Angelic M G, Sibiryak Darya S, Bakdash Ghaith, van Capel Toni M M, van der Kleij Hanneke P M, Opstelten Dirk-Jan E, Teunissen Marcel B M, Kapsenberg Martien L, de Jong Esther C
Abstract excerpt
BACKGROUND: The vitamin D metabolite 1,25(OH)2D3 (VitD3) is a potent immunosuppressive drug and, among others, is used for topical treatment of psoriasis. A proposed mechanism of VitD3-mediated suppression is priming of dendritic cells (DCs) to induce regulatory T (Treg) cells. OBJECTIVE: Currently, there is confusion about the phenotype of VitD3-induced Treg cells and the DC-derived molecules driving their...
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