Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes.

doi:10.1186/s12967-016-1090-7

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Article

Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes.

Journal of translational medicine - 1 Dec 2016

Marek-Trzonkowska Natalia, Myśliwiec Małgorzata, Iwaszkiewicz-Grześ Dorota, Gliwiński Mateusz, Derkowska Ilona, Żalińska Magdalena, Zieliński Maciej, Grabowska Marcelina, Zielińska Hanna, Piekarska Karolina, Jaźwińska-Curyłło Anna, Owczuk Radosław, Szadkowska Agnieszka, Wyka Krystyna, Witkowski Piotr, Młynarski Wojciech, Jarosz-Chobot Przemysława, Bossowski Artur, Siebert Janusz, Trzonkowski Piotr

Abstract excerpt

BACKGROUND: Recent studies suggest that immunotherapy using T regulatory cells (Tregs) prolongs remission in type 1 diabetes (T1DM). Here, we report factors that possibly affect the efficacy of this treatment. METHODS: The metabolic and immune background of 12 children with recently diagnosed T1DM, as well as that of untreated subjects, during a 2-year follow-up is presented. Patients were treated with up to...

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PMID: 27903296
DOI: 10.1186/s12967-016-1090-7
PMCID: PMC5131539

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