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Article

Decreased CD127 expression on CD4+ T-cells and elevated frequencies of CD4+CD25+CD127- T-cells in children with long-lasting type 1 diabetes.

Clinical & developmental immunology - 1 Jan 2013

Moniuszko Marcin, Glowinska-Olszewska Barbara, Rusak Malgorzata, Jeznach Marta, Grubczak Kamil, Lipinska Danuta, Milewski Robert, Milewska Anna Justyna, Dabrowska Milena, Jablonska Ewa, Kretowski Adam, Gorska Maria, Bodzenta-Lukaszyk Anna, Bossowski Artur

Abstract excerpt

Pathobiology of type 1 diabetes (T1D) is predominantly associated with T-cell-related actions. Homeostasis of majority of T-cells is critically dependent on signals mediated by CD127 (interleukin-7 receptor, IL-7R). In contrast, regulatory T-cells express very little CD127 and thereby may be delineated by CD4+CD25+CD127- phenotype. Here we aimed to analyze CD127 expression on CD4+ and CD8+ T-cells and enumerate...

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Identifiers

PMID: 24348676
DOI: 10.1155/2013/459210
PMCID: PMC3856128

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