Article
Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function.
European journal of immunology - 1 Oct 2005
Jarvis Lorna B, Matyszak Malgosia K, Duggleby Richard C, Goodall Jane C, Hall Frances C, Gaston J S Hill
Abstract excerpt
Despite substantial advances in our understanding of CD4+ CD25+ regulatory T cells, a possible equivalent regulatory subset within the CD8+ T cell population has received less attention. We now describe novel human CD8+/TCR alphabeta+ T cells that have a regulatory phenotype and function. We expanded and cloned these cells using autologous LPS-activated dendritic cells. The clones were not cytolytic, but...
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