Article
Telomere stability and development of ctc1 mutants are rescued by inhibition of EJ recombination pathways in a telomerase-dependent manner.
Nucleic acids research - 29 Oct 2014
Amiard Simon, Olivier Margaux, Allain Elisabeth, Choi Kyuha, Smith-Unna Richard, Henderson Ian R, White Charles I, Gallego Maria Eugenia
Abstract excerpt
The telomeres of linear eukaryotic chromosomes are protected by caps consisting of evolutionarily conserved nucleoprotein complexes. Telomere dysfunction leads to recombination of chromosome ends and this can result in fusions which initiate chromosomal breakage-fusion-bridge cycles, causing genomic instability and potentially cell death or cancer. We hypothesize that in the absence of the recombination pathways...
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