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Article

Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.

Molecular cell - 23 Oct 2009

Surovtseva Yulia V, Churikov Dmitri, Boltz Kara A, Song Xiangyu, Lamb Jonathan C, Warrington Ross, Leehy Katherine, Heacock Michelle, Price Carolyn M, Shippen Dorothy E

Abstract excerpt

Orthologs of the yeast telomere protein Stn1 are present in plants, but other components of the Cdc13/Stn1/Ten1 (CST) complex have only been found in fungi. Here we report the identification of conserved telomere maintenance component 1 (CTC1) in plants and vertebrates. CTC1 encodes an approximately 140 kDa telomere-associated protein predicted to contain multiple OB-fold domains. Arabidopsis mutants null for...

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Source

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Identifiers

PMID: 19854131
DOI: 10.1016/j.molcel.2009.09.017
PMCID: PMC2768651

Genes

CTC1
STN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.PMID 19854131Read ↗

MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in Arabidopsis.Semantic proximity Read ↗

STN1 protects chromosome ends in Arabidopsis thaliana.Semantic proximity Read ↗

Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis.Semantic proximity Read ↗

Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis.Semantic proximity Read ↗

CTC1-mediated C-strand fill-in is an essential step in telomere length maintenanceSemantic proximity Read ↗

Protection of telomeres by a conserved Stn1–Ten1 complexSemantic proximity Read ↗

Structure of the Human Telomeric Stn1-Ten1 Capping ComplexSemantic proximity Read ↗

Human TEN1 Maintains Telomere Integrity and Functions in Genome-wide Replication RestartSemantic proximity Read ↗

Conditional deletion of human STN1 leads to telomere dysfunction and telomerase-dependent genome instability and proliferation defectsSemantic proximity Read ↗

Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13.Semantic proximity Read ↗

TEN1 is essential for CDC13-mediated telomere capping.Semantic proximity Read ↗

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