Article
Ku suppresses formation of telomeric circles and alternative telomere lengthening in Arabidopsis.
Molecular cell - 6 Jul 2007
Zellinger Barbara, Akimcheva Svetlana, Puizina Jasna, Schirato Martina, Riha Karel
Abstract excerpt
Telomeres in mammals and plants are protected by the terminal t loop structure, the formation of which parallels the first steps of intrachromatid homologous recombination (HR). Under some circumstances, cells can also utilize an HR-based mechanism (alternative lengthening of telomeres [ALT]) as a back-up pathway for telomere maintenance. We have found that the Ku70/80 heterodimer, a central nonhomologous...
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