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Article

ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis.

Molecular biology of the cell - 1 Apr 2012

Boltz Kara A, Leehy Katherine, Song Xiangyu, Nelson Andrew D, Shippen Dorothy E

Abstract excerpt

The CTC1/STN1/TEN1 (CST) complex is an essential constituent of plant and vertebrate telomeres. Here we show that CST and ATR (ataxia telangiectasia mutated [ATM] and Rad3-related) act synergistically to maintain telomere length and genome stability in Arabidopsis. Inactivation of ATR, but not ATM, temporarily rescued severe morphological phenotypes associated with ctc1 or stn1. Unexpectedly, telomere shortening...

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Source

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Identifiers

PMID: 22357613
DOI: 10.1091/mbc.E11-12-1002
PMCID: PMC3327312

Genes

ATR
ATM
CTC1
STN1
TEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis.PMID 22357613Read ↗

Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.Semantic proximity Read ↗

MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in Arabidopsis.Semantic proximity Read ↗

ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in Arabidopsis.Semantic proximity Read ↗

Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis.Semantic proximity Read ↗

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CTC1-mediated C-strand fill-in is an essential step in telomere length maintenanceSemantic proximity Read ↗

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