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Article

Disruption of the Arabidopsis AtKu80 gene demonstrates an essential role for AtKu80 protein in efficient repair of DNA double-strand breaks in vivo.

The Plant journal : for cell and molecular biology - 1 Aug 2002

West Christopher E, Waterworth Wanda M, Story Geraint W, Sunderland Paul A, Jiang Qing, Bray Clifford M

Abstract excerpt

Double-strand breaks (DSBs) in DNA may occur spontaneously in the cell or be induced experimentally by gamma-irradiation, and represent one of the most serious threats to genomic integrity. Non-homologous end joining (NHEJ) rather than homologous recombination appears to be the major pathway for DSB repair in humans and plants, and it may also be the major route whereby T-DNA integrates into the plant genome...

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Identifiers

PMID: 12182708
DOI: 10.1046/j.1365-313x.2002.01370.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of the Arabidopsis AtKu80 gene demonstrates an essential role for AtKu80 protein in efficient repair of DNA double-strand breaks in vivo.PMID 12182708Read ↗

Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis.Semantic proximity Read ↗

Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70.Semantic proximity Read ↗

Ku80 plays a role in non-homologous recombination but is not required for T-DNA integration in Arabidopsis.Semantic proximity Read ↗

Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant.Semantic proximity Read ↗

Involvement of KU80 in T-DNA integration in plant cells.Semantic proximity Read ↗

Telomerase dependence of telomere lengthening in Ku80 mutant Arabidopsis.Semantic proximity Read ↗

Characterization of gamma irradiation-induced mutations in Arabidopsis mutants deficient in non-homologous end joining.Semantic proximity Read ↗

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance.Semantic proximity Read ↗

OsKu70 is associated with developmental growth and genome stability in rice.Semantic proximity Read ↗

Ku80- and DNA ligase IV-deficient plants are sensitive to ionizing radiation and defective in T-DNA integration.Semantic proximity Read ↗

Ku suppresses formation of telomeric circles and alternative telomere lengthening in Arabidopsis.Semantic proximity Read ↗

The Multifaceted Roles of Ku70/80Semantic proximity Read ↗

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