Article
End joining at Caenorhabditis elegans telomeres.
Genetics - 1 Oct 2008
Lowden Mia Rochelle, Meier Bettina, Lee Teresa Wei-Sy, Hall Julie, Ahmed Shawn
Abstract excerpt
Critically shortened telomeres can be subjected to DNA repair events that generate end-to-end chromosome fusions. The resulting dicentric chromosomes can enter breakage-fusion-bridge cycles, thereby impeding elucidation of the structures of the initial fusion events and a mechanistic understanding of their genesis. Current models for the molecular basis of fusion of critically shortened, uncapped telomeres rely...
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