Article
The individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heart.
FEBS letters - 3 Nov 2014
Shao Dongxue, Zhao Meimi, Xu Jianjun, Feng Rui, Guo Feng, Hu Huiyuan, Sun Xuefei, Gao Qinghua, He Guilin, Sun Wei, Wang Hongmei, Yu Lifeng, Liu Suyuan, Zhu Yaonan, Minobe Etsuko, Zhu Tong, Kameyama Masaki, Hao Liying
Abstract excerpt
The present study examined the binding of the individual N- and C-lobes of calmodulin (CaM) to Cav1.2 at different Ca(2+) concentration ([Ca(2+)]) from ≈ free to 2mM, and found that they may bind to Cav1.2 Ca(2+)-dependently. In particular, using the patch-clamp technique, we confirmed that the N- or C-lobes can rescue the basal activity of Cav1.2 from run-down, demonstrating the functional relevance of the...
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