Calmodulin regulation of excitation-contraction coupling in cardiac myocytes.

doi:10.1161/01.RES.0000064566.91495.0C

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Calmodulin regulation of excitation-contraction coupling in cardiac myocytes.

Circulation research - 4 Apr 2003

Yang Dongmei, Song Long-Sheng, Zhu Wei-Zhong, Chakir Khalid, Wang Wei, Wu Caihong, Wang Yibin, Xiao Rui-Ping, Chen S R Wayne, Cheng Heping

Abstract excerpt

Calmodulin (CaM) as a ubiquitous Ca2+ sensor interacts with multiple key molecules involved in excitation-contraction (EC) coupling. In the present study, we report that adenoviral expression of a mutant CaM lacking all of its four Ca2+-binding sites, CaM(1-4), at a level 6.5-fold over endogenous CaM markedly increases the amplitude and abbreviates the decay time of Ca2+ transients and contraction in cultured rat...

Topics

Animals
Calcium
Calcium Channels, L-Type
Calcium Signaling
Calcium-Binding Proteins
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Calmodulin
Cells, Cultured
Electric Conductivity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Myocardial Contraction

Myocytes, Cardiac

Patch-Clamp Techniques

Phosphorylation

Rats

Rats, Sprague-Dawley

Sarcoplasmic Reticulum

Source

Open in PubMed

Identifiers

PMID: 12609973
DOI: 10.1161/01.RES.0000064566.91495.0C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calmodulin regulation of excitation-contraction coupling in cardiac myocytes.PMID 12609973Read ↗

Elementary mechanisms of calmodulin regulation of NaV1.5 producing divergent arrhythmogenic phenotypes.Semantic proximity Read ↗

Role of cardiac ryanodine receptor calmodulin-binding domains in mediating the action of arrhythmogenic calmodulin N-domain mutation N54I.Semantic proximity Read ↗

Arrhythmogenic calmodulin mutations disrupt intracellular cardiomyocyte Ca2+ regulation by distinct mechanisms.Semantic proximity Read ↗

Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense MutantsSemantic proximity Read ↗

Calmodulinopathy: Functional Effects of CALM Mutations and Their Relationship With Clinical PhenotypesSemantic proximity Read ↗

Calmodulin limits pathogenic Na+ channel persistent current.Semantic proximity Read ↗

Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia.Semantic proximity Read ↗

Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function.Semantic proximity Read ↗

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes.Semantic proximity Read ↗

The IQ motif is crucial for Cav1.1 function.Semantic proximity Read ↗

Inhibition of calcium/calmodulin (Ca 2+ /CaM)—Calcium/calmodulin‐dependent protein kinase II (CaMKII) axis reduces in vitro and ex vivo arrhythmias in experimental Chagas diseaseSemantic proximity Read ↗

Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.