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Article

Half-calcified calmodulin promotes basal activity and inactivation of the L-type calcium channel CaV1.2.

The Journal of biological chemistry - 1 Dec 2022

Bartels Peter, Salveson Ian, Coleman Andrea M, Anderson David E, Jeng Grace, Estrada-Tobar Zoila M, Man Kwun Nok Mimi, Yu Qinhong, Kuzmenkina Elza, Nieves-Cintron Madeline, Navedo Manuel F, Horne Mary C, Hell Johannes W, Ames James B

Abstract excerpt

The L-type Ca2+ channel CaV1.2 controls gene expression, cardiac contraction, and neuronal activity. Calmodulin (CaM) governs CaV1.2 open probability (Po) and Ca2+-dependent inactivation (CDI) but the mechanisms remain unclear. Here, we present electrophysiological data that identify a half Ca2+-saturated CaM species (Ca2/CaM) with Ca2+ bound solely at the third and fourth EF-hands (EF3 and EF4) under resting...

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Identifiers

PMID: 36395884
DOI: 10.1016/j.jbc.2022.102701
PMCID: PMC9764201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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