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Article

A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.

Structure (London, England : 1993) - 1 May 2018

Johnson Christopher N, Potet Franck, Thompson Matthew K, Kroncke Brett M, Glazer Andrew M, Voehler Markus W, Knollmann Bjorn C, George Alfred L, Chazin Walter J

Abstract excerpt

The function of the human cardiac sodium channel (NaV1.5) is modulated by the Ca2+ sensor calmodulin (CaM), but the underlying mechanism(s) are controversial and poorly defined. CaM has been reported to bind in a Ca2+-dependent manner to two sites in the intracellular loop that is critical for inactivation of NaV1.5 (inactivation gate [IG]). The affinity of CaM for the complete IG was significantly stronger than...

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Identifiers

PMID: 29606593
DOI: 10.1016/j.str.2018.03.005
PMCID: PMC5932218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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