Article
NaV1.2 EFL domain allosterically enhances Ca2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD.
Structure (London, England : 1993) - 2 Dec 2021
Mahling Ryan, Hovey Liam, Isbell Holly M, Marx Dagan C, Miller Mark S, Kilpatrick Adina M, Weaver Lisa D, Yoder Jesse B, Kim Elaine H, Andresen Corinne N J, Li Shuxiang, Shea Madeline A
Abstract excerpt
Neuronal voltage-gated sodium channel NaV1.2 C-terminal domain (CTD) binds calmodulin (CaM) constitutively at its IQ motif. A solution structure (6BUT) and other NMR evidence showed that the CaM N domain (CaMN) is structurally independent of the C-domain (CaMC) whether CaM is bound to the NaV1.2IQp (1,901-1,927) or NaV1.2CTD (1,777-1,937) with or without calcium. However, in the CaM + NaV1.2CTD complex, the Ca2+...
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