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Article

Molecular basis of calmodulin binding to cardiac muscle Ca(2+) release channel (ryanodine receptor).

The Journal of biological chemistry - 27 Jun 2003

Yamaguchi Naohiro, Xu Le, Pasek Daniel A, Evans Kelly E, Meissner Gerhard

Abstract excerpt

Calmodulin (CaM) is a ubiquitous Ca2+-binding protein that regulates the ryanodine receptors (RyRs) by direct binding. CaM inhibits the skeletal muscle ryanodine receptor (RyR1) and cardiac muscle receptor (RyR2) at >1 microm Ca2+ but activates RyR1 and inhibits RyR2 at <1 microm Ca2+. Here we tested whether CaM regulates RyR2 by binding to a highly conserved site identified previously in RyR1. Deletion of RyR2...

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Identifiers

PMID: 12707260
DOI: 10.1074/jbc.M301125200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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