[Effect of calmodulin and its mutants on binding to NaV1.2 IQ].

doi:10.3785/j.issn.1008-9292.2020.02.06

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Article

[Effect of calmodulin and its mutants on binding to NaV1.2 IQ].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences - 25 May 2020

Wan Yujun, Liu Junyan, Wang Yuting, Cheng Xiaoyu, Sha Sha, Jia Wanying, Hu Delin, Li Xinyu, Guo Feng

Abstract excerpt

OBJECTIVE: To investigate the effect of calmodulin (CaM) and its mutants on binding to voltage-gated Na channel isoleucine-glutamine domain (NaV1.2 IQ). METHODS: The cDNA of NaV1.2 IQ was constructed by PCR technique, CaM mutants CaM12, CaM34 and CaM1234 were constructed with QuickchangeTM site-directed mutagenesis kit (QIAGEN). The binding of NaV1.2 IQ to CaM and CaM mutants under calcium and calcium free...

Topics

Calcium
Calmodulin
Mutation
NAV1.2 Voltage-Gated Sodium Channel
Protein Binding

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Identifiers

PMID: 32621420
DOI: 10.3785/j.issn.1008-9292.2020.02.06
PMCID: PMC8800744

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