Article
Calmodulin regulates Ca2+-sensing receptor-mediated Ca2+ signaling and its cell surface expression.
The Journal of biological chemistry - 12 Nov 2010
Huang Yun, Zhou Yubin, Wong Hing-Cheung, Castiblanco Adriana, Chen Yanyi, Brown Edward M, Yang Jenny J
Abstract excerpt
The Ca(2+)-sensing receptor (CaSR) is a member of family C of the GPCRs responsible for sensing extracellular Ca(2+) ([Ca(2+)](o)) levels, maintaining extracellular Ca(2+) homeostasis, and transducing Ca(2+) signaling from the extracellular milieu to the intracellular environment. In the present study, we have demonstrated a Ca(2+)-dependent, stoichiometric interaction between CaM and a CaM-binding domain (CaMBD)...
Topics
- Algorithms
- Amino Acid Sequence
- Binding Sites
- Calcium
- Calcium Signaling
- Calmodulin
- Cell Membrane
- Circular Dichroism
- Flow Cytometry
- HEK293 Cells
- Humans
- Immunoprecipitation
- Intracellular Space
- Kinetics