Article
Lobe-related concentration- and Ca(2+)-dependent interactions of calmodulin with C- and N-terminal tails of the CaV1.2 channel.
The journal of physiological sciences : JPS - 1 Sept 2013
He Guilin, Guo Feng, Zhu Tong, Shao Dongxue, Feng Rui, Yin Dandan, Sun Xuefei, Hu Huiyuan, Hwang Ahhyeon, Minobe Etsuko, Kameyama Masaki, Hao Liying
Abstract excerpt
This study examined the bindings of calmodulin (CaM) and its mutants with the C- and N-terminal tails of the voltage-gated Ca(2+) channel CaV1.2 at different CaM and Ca(2+) concentrations ([Ca(2+)]) by using the pull-down assay method to obtain basic information on the binding mode, including its concentration- and Ca(2+)-dependencies. Our data show that more than one CaM molecule could bind to the CaV1.2...
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