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Article

Characterization of the calmodulin-binding site in the N terminus of CaV1.2.

Channels (Austin, Tex.) - 1 Jan 2000

Benmocha Adva, Almagor Lior, Oz Shimrit, Hirsch Joel A, Dascal Nathan

Abstract excerpt

Interaction of calmodulin (CaM) with the C-terminus (CT) of the L-type Ca(V)1.2 channel is crucial for Ca(2+)-dependent inactivation (CDI). CaM also binds to the N-terminus (NT), and a CaM-formed "bridge" between CT and NT has been proposed to control CDI. We characterized the interaction of CaM with its NT-binding peptide. Binding is Ca(2+)-dependent with an affinity of 0.6 microM. Mutations in NT of Ca(V)1.2...

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Identifiers

PMID: 19713738
DOI: 10.4161/chan.3.5.9686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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