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Article

The Effect of Ca2+, Lobe-Specificity, and CaMKII on CaM Binding to NaV1.1.

International journal of molecular sciences - 23 Aug 2018

Li Jianing, Yu Zhiyi, Xu Jianjun, Feng Rui, Gao Qinghua, Boczek Tomasz, Liu Junyan, Li Zhi, Wang Qianhui, Lei Ming, Gong Jian, Hu Huiyuan, Minobe Etsuko, Ji Hong-Long, Kameyama Masaki, Guo Feng

Abstract excerpt

Calmodulin (CaM) is well known as an activator of calcium/calmodulin-dependent protein kinase II (CaMKII). Voltage-gated sodium channels (VGSCs) are basic signaling molecules in excitable cells and are crucial molecular targets for nervous system agents. However, the way in which Ca2+/CaM/CaMKII cascade modulates NaV1.1 IQ (isoleucine and glutamine) domain of VGSCs remains obscure. In this study, the binding of...

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Identifiers

PMID: 30142967
DOI: 10.3390/ijms19092495
PMCID: PMC6165294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Effect of Ca2+, Lobe-Specificity, and CaMKII on CaM Binding to NaV1.1.PMID 30142967Read ↗

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