Article
The Effect of Ca2+, Lobe-Specificity, and CaMKII on CaM Binding to NaV1.1.
International journal of molecular sciences - 23 Aug 2018
Li Jianing, Yu Zhiyi, Xu Jianjun, Feng Rui, Gao Qinghua, Boczek Tomasz, Liu Junyan, Li Zhi, Wang Qianhui, Lei Ming, Gong Jian, Hu Huiyuan, Minobe Etsuko, Ji Hong-Long, Kameyama Masaki, Guo Feng
Abstract excerpt
Calmodulin (CaM) is well known as an activator of calcium/calmodulin-dependent protein kinase II (CaMKII). Voltage-gated sodium channels (VGSCs) are basic signaling molecules in excitable cells and are crucial molecular targets for nervous system agents. However, the way in which Ca2+/CaM/CaMKII cascade modulates NaV1.1 IQ (isoleucine and glutamine) domain of VGSCs remains obscure. In this study, the binding of...
Topics
- Amino Acid Sequence
- Binding Sites
- Calcium
- Calcium-Calmodulin-Dependent Protein Kinase Type 2
- Calmodulin
- Cloning, Molecular
- Crystallography, X-Ray
- Escherichia coli
- Gene Expression
- Genetic Vectors