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Article

Reciprocal actions of REST and a microRNA promote neuronal identity.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006

Conaco Cecilia, Otto Stefanie, Han Jong-Jin, Mandel Gail

Abstract excerpt

MicroRNAs (miRNAs) are implicated in both tissue differentiation and maintenance of tissue identity. In most cases, however, the mechanisms underlying their regulation are not known. One brain-specific miRNA, miR-124a, decreases the levels of hundreds of nonneuronal transcripts, such that its introduction into HeLa cells promotes a neuronal-like mRNA profile. The transcriptional repressor, RE1 silencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16461918
DOI: 10.1073/pnas.0511041103
PMCID: PMC1413753

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reciprocal actions of REST and a microRNA promote neuronal identity.PMID 16461918Read ↗

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Nontelomeric splice variant of telomere repeat-binding factor 2 maintains neuronal traits by sequestering repressor element 1-silencing transcription factorSemantic proximity Read ↗

MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron DegenerationSemantic proximity Read ↗

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