Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormal development of monoaminergic neurons is implicated in mood fluctuations and bipolar disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2015

Jukic Marin M, Carrillo-Roa Tania, Bar Michal, Becker Gal, Jovanovic Vukasin M, Zega Ksenija, Binder Elisabeth B, Brodski Claude

Abstract excerpt

Subtle mood fluctuations are normal emotional experiences, whereas drastic mood swings can be a manifestation of bipolar disorder (BPD). Despite their importance for normal and pathological behavior, the mechanisms underlying endogenous mood instability are largely unknown. During embryogenesis, the transcription factor Otx2 orchestrates the genetic networks directing the specification of dopaminergic (DA) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to Biogenic Monoamines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dark Adaptation

Share to Developmental Disabilities

Share to Exploratory Behavior

Share to Maze Learning

Share to Mood Disorders

Share to Otx Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 25241801
DOI: 10.1038/npp.2014.244
PMCID: PMC4330498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal development of monoaminergic neurons is implicated in mood fluctuations and bipolar disorder.PMID 25241801Read ↗

Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice.Semantic proximity Read ↗

A suite of engineered mice for interrogating psychedelic drug actionsSemantic proximity Read ↗

Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.Semantic proximity Read ↗

A new mouse model for mania shares genetic correlates with human bipolar disorder.Semantic proximity Read ↗

New lessons from knockout mice: The role of serotonin during development and its possible contribution to the origins of neuropsychiatric disorders.Semantic proximity Read ↗

Selective genetic disruption of dopaminergic, serotonergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behaviour.Semantic proximity Read ↗

Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.Semantic proximity Read ↗

Serotonin system development and adult function are regulated by GDNFSemantic proximity Read ↗

Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour.Semantic proximity Read ↗

Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.Semantic proximity Read ↗

Human neuromodulatory assembloids to study serotonin signaling and diseaseSemantic proximity Read ↗

Polymorphisms in the homeobox gene OTX2 may be a risk factor for bipolar disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.