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Article

Polymorphisms in the homeobox gene OTX2 may be a risk factor for bipolar disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2007

Sabunciyan Sarven, Yolken Robert, Ragan Christina M, Potash James B, Nimgaonkar Vishwajit L, Dickerson Faith, Llenos Ida C, Weis Serge

Abstract excerpt

We investigated the possible involvement of OTX2, a homeobox gene crucial for forebrain development, in the pathogenesis of schizophrenia and bipolar disorder. The disruption of this gene results in cortical malformations and causes serotonergic and dopaminergic cells in the midbrain to be expres...

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Identifiers

PMID: 17541950
DOI: 10.1002/ajmg.b.30523

Genes

OTX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17541950-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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